Procedure for preparation and standardization 0.1 N Lithium Methoxide in Methanol

1. OBJECTIVE
To lay down the procedure for preparation and standardization of 0.1 N Lithium Methoxide in methanol

2. SCOPE
This procedure is applicable to Quality Control Department

3. RESPONSIBILITY
• Officer QC
• Manager QC

4. SAFETY INSTRUCTIONS
• Proper handling the apparatus.
• As lithium compounds are highly reactive and flammable. Therefore, it is recommended to wear gloves and protective eyewear when handling lithium methoxide.
• Additionally, it is important to weigh the chemical accurately and dissolve it completely to ensure the desired concentration of the solution.

5. PROCEDURE
5.1 PREPARATION
5.1.1 Dissolve 500 mg of freshly cut lithium metal in 150 mL of methanol, cooling the flask during addition of the metal.
5.1.2 When reaction is complete, add 850 mL of methanol.
5.1.3 If cloudiness or precipitation occurs, add sufficient methanol to clarify the solution.
5.1.4 Store preferably in the reservoir of an automatic delivery burette suitably protected from carbon dioxide and moisture.
5.2 STANDARDIZATION
5.2.1 Accurately Standardize the solution by titration against benzoic acid as described under Sodium Methoxide (0.1 N) (in Toluene).
5.2.2 And calculate the normality by the following formula:

            mg of Benzoic acid
N= ———————————————————————————-
         122.1 x ml of lithium methoxide (Correced for blank)

6. RELATED DOCUMENTS
N/A

7. DISTRIBUTION INDEX
Original Copy will be retained by Quality Assurance Department.

8. ABBREVIATIONS
Q.C Quality Control Department
TS Test Solution
Gm Gram
ml Milliliter

9. REVISION HISTORY